مطالعه اثرات ضدباروری یک مشتق جدید Nifedipine در موشهای صحرائی نر بالغ

1,4dihydro&nbsp;2,6dimethyl 4 4.nitrophenyl)&nbsp; , 5pyridinedicarboxylic acid&nbsp;dimethyl ester (DDNPD), is a new&nbsp;analogus of nifedipine that has no effect&nbsp;on calcium channels of cardiovascular system. Because&nbsp;nifedipine can&nbsp;reduce fertility in males( through effect on calcium channels on sperm&nbsp;membrane&nbsp;and inhibition of acrosomal&nbsp;reaction), this study&nbsp;was done&nbsp;to&nbsp; evaluate&nbsp;the effect of&nbsp;DDNPD on&nbsp;reproductive system physiology and&nbsp;fertility in&nbsp;male rats. &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; In this research, DDNPD was injected 10mg/kg twice a day subcutaneously&nbsp;to the test group of adult male rats for 50 days.&nbsp;Control group&nbsp;treated with&nbsp;propylene glycol 1mg/kg twice a day in the same way. &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; In the assessment&nbsp;of some fertility&nbsp;indices ,&nbsp;we saw a significant&nbsp;decrease in motility and viability&nbsp;rate of sperm (P<0.001), the epididymal&nbsp;sperm reserve&nbsp;rate (P<0.001) and&nbsp;fertility rate&nbsp;(P<0.001) in the test group&nbsp;but there was no difference&nbsp;in testosterone level&nbsp;between&nbsp;the&nbsp;groups. &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; These results are conclusive of posttesticular antifertility effect of DDNPD&nbsp;if injected&nbsp;10mg/kg&nbsp;for 50 days&nbsp;to male adult rats.